End-to-End Workflow Solutions for Short Nucleic Acids and mRNA Analysis

Short synthetic oligonucleotides, such as small interfering RNA, antisense oligonucleotides, aptamers, and CRISPR guides have gained much attention and grown rapidly as a new type of drug in gene therapy. The success of mRNA vaccines for COVID-19 and recent oligonucleotide-based therapeutics has generated an explosion of interest in both academia and the pharmaceutical industry. As a result, there are growing needs and many opportunities for robust analytical QC methods in the development and characterization of these nucleic acids and mRNA vaccine products

This guide explores the multiple workflows available and the instruments designed to improve analysis, purification, and quality control of oligo production. Also discussed are the advanced features and capabilities of analysis software driving these instruments.