Mass Spectrometry, Large Biomolecules, and the Science of “More”

A conversation with Dr. Brandon Ruotolo, Professor and Associate Chair for Research, University of Michigan, Department of Chemistry

Mass spectrometry has a long and celebrated history as a foundational technique in biochemistry. Its
ability to cleave molecules into charged fragments, then sort those fragments according to their mass-
to-charge ratio, has been harnessed countless times to identify and quantitate a broad range of
molecules of significant biological interest.

There’s no denying that a tremendous wealth of knowledge has been – and continues to be – added to
our understanding of biomolecular structure and function using these techniques. But occasionally the
question arises: Are there ways we could improve, modify, or otherwise tweak this approach to tell us
even more, even faster?

Dr. Brandon Ruotolo, professor of chemistry at the University of Michigan, and colleagues are looking
for ways to make mass spectrometry analysis of macromolecules more quantitative, more nuanced,
more information rich, and more reflective of the contextual reality of biomolecular structure, function,
and interaction.

Download this case study report to learn more. Discussion topics include:

Native mass spectrometry and the influences of sample preparation and ionization
Collision-induced unfolding using Ion Mobility Q-TOF
Scale up, meta-analysis, and big data solutions

DOWNLOAD THIS CASE STUDY TO LEARN MORE

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