Molecular Devices Axon Multiclamp 700B

A microelectrode amplifier that combines leading edge electronics design and a wealth of features and functions with an intuitive user interface that simplifies the creation of complex protocols.The Multiclamp™ 700B Microelectrode Amplifier combines leading edge electronics design and a wealth of features and functions with an intuitive user interface that simplifies the creation of complex protocols.

The applications for this amplifier comprise a wide variety of intracellular or extracellular recordings in electrophysiology, including: 

• Patch clamp (whole-cell, macro-patch, or excised patch) 
• High-speed current clamp (sharp-electrode or field potentials) 
• Voltammetry/amperometry 
• Ion-selective measurements 
• Bilayer recordings 

With two independent primary headstages and an additional two auxiliary headstages, the Multiclamp 700B Microelectrode Amplifier houses the solution for almost any conceivable electrophysiology recording in one slim, convenient package. Instead of front panel knobs and switches, the MultiClamp 700B Amplifier is controlled by Multiclamp 700B Commander software, a program that runs on a host computer (PC and Macintosh; see Requirements below) and communicates with the amplifier via a USB interface. The intuitive user interface of MultiClamp Commander gives the operator full control of all amplifier functions, while the Quick Select feature enables easy access to saved configurations that apply to particular recording configurations. The optional, user-configurable SoftPanel lets you operate the most commonly used controls using traditional knobs and buttons.    The Multiclamp 700B Amplifier comes standard with two independent CV-7B headstages, each of which contains both current-to-voltage and voltage-following circuitry. This design allows the user to rapidly switch between patch clamp recording and true high-speed current clamp recording. Thus, with two headstages, the Multiclamp 700B Amplifier can perform the function of two patch clamp amplifiers, two current clamp amplifiers, or a combination of patch and current clamp amplifiers. Furthermore, two optional voltage-follower headstages (HS-2 type) can be connected to auxiliary inputs to allow third- and fourth-point voltage recording.    Major new features of the Multiclamp 700 B Amplifier include Internal Automatic Mode switching, triggered by external signals or the recording itself; Oscillation Suppression for better cell protection; and Slow Current Injection to compensate for drifting potentials. For more information and a full listing of features and specifications, go to the Specifications tab below or download the manual in the Downloads section.